General Information

  • ID:  hor006024
  • Uniprot ID:  P87385
  • Protein name:  somatostatin-14
  • Gene name:  sst2
  • Organism:  Pelophylax ridibundus (Marsh frog) (Rana ridibunda)
  • Family:  Somatostatin family
  • Source:  animal
  • Expression:  NA
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:   Pelophylax (genus), Ranidae (family), Ranoidea (superfamily), Neobatrachia (suborder), Anura (order), Batrachia (superorder), Amphibia (class), Tetrapoda , Dipnotetrapodomorpha , Sarcopterygii (superclass), Euteleostomi , Teleostomi , Gnathostomata , Vertebrata , Craniata (subphylum), Chordata (phylum), Deuterostomia , Bilateria , Eumetazoa , Metazoa (kingdom), Opisthokonta , Eukaryota (superkingdom),cellular organisms
  • GO MF:  GO:0005179 hormone activity
  • GO BP:  GO:0007165 signal transduction
  • GO CC:  GO:0005576 extracellular region

Sequence Information

  • Sequence:  APCKNFFWKTFTMC
  • Length:  14(90-103)
  • Propeptide:  MLGSAGTLLLLLLAWGARALSQPDDNRITTGRNQDLNAIQQDLLLKLLSGWTDSRESNLVEVERNVPDPPEPKIPPSVKFPRLSLRERKAPCKNFFWKTFTMC
  • Signal peptide:  MLGSAGTLLLLLLAWGARALS
  • Modification:  NA
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  Somatostatin inhibits the release of somatotropin.
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  45730
  • Structure ID:  AF-P87385-F1(AlphaFold_DB_ID)

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    hor006024_AF2.pdbhor006024_ESM.pdb

Physical Information

Mass: 195614 Formula: C81H114N18O18S3
Absent amino acids: DEGHILQRSVY Common amino acids: F
pI: 8.82 Basic residues: 2
Polar residues: 5 Hydrophobic residues: 5
Hydrophobicity: 13.57 Boman Index: -489
Half-Life: 4.4 hour Half-Life Yeast: >20 hour
Half-Life E.Coli: >10 hour Aliphatic Index 7.14
Instability Index: 1573.57 Extinction Coefficient cystines: 5625
Absorbance 280nm: 432.69

Literature

  • PubMed ID:  8901629
  • Title:  Occurrence of two somatostatin variants in the frog brain: characterization of the cDNAs, distribution of the mRNAs, and receptor-binding affinities of the peptides.
  • PubMed ID:  1358069
  • Title:  Isolation of [Pro2,Met13]somatostatin-14 and somatostatin-14 from the frog brain reveals